Thymulin bibliography
My leishmaniasis question has difficult company in the chemistry and endocrine papers.
Skin, brain and nerve injury
The mouse skin-infection paper gives the home essay its question about heightened sensitivity and an unchanged baseline. The rat brain-endotoxin experiment changes both route and challenge.
For PAT, the chronic constriction injury study and the brain-endotoxin study test a thymulin analogue. The rat inflammatory-pain study involving spinal signalling uses thymulin itself. The preparation names do useful work for me here: they stop related findings from becoming a single sprawling claim.
Zinc chemistry and endocrine experiments
The zinc-interaction review addresses the peptide's active form. The human marrow-precursor cell study concerns T-cell markers in culture, while the rat pituitary-cell study measures ACTH release.
The thymus–neuroendocrine review gives those connections a wider physiological setting. The athymic-mouse gene-therapy paper follows a different preparation into hormone development.
Human rheumatology studies
The controlled nonathymulin trials and the open FTS-Zn trial both involved rheumatoid-arthritis patients. Their designs and preparations differ.
The full citation details follow.
- Thymulin reduces the hyperalgesia and cytokine upregulation induced by cutaneous leishmaniasis in mice ↗
- Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection ↗
- Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways ↗
- A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin ↗
- Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection ↗
- Thymulin stimulates corticotrophin release and cyclic nucleotide formation in the rat anterior pituitary gland ↗
- The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin ↗
- Interactions between zinc and thymulin ↗
- Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS ↗
- Nonathymulin in rheumatoid arthritis: two double blind, placebo controlled trials ↗
- An open trial of thymulin (FTS-Zn) in rheumatoid arthritis patients: sequential clinical and immunological follow-up ↗
- Thymulin-based gene therapy and pituitary function in animal models of aging ↗